DisV-HPV16, versatile and powerful software to detect HPV in RNA sequencing data.

ABSTRACT:

Background

The increasing availability of high-throughput sequencing data provides researchers with unprecedented opportunities to investigate viral genetic elements in host genomes that contribute to virus-linked cancers. Almost all of the available computational tools for secondary analysis of sequencing data detect viral infection or genome integration events. However, viral oncogenes expression is likely of importance in carcinoma. We therefore developed a new software, DisV-HPV16, for the evaluation of HPV16 oncogenes expression.

Results

HPV16 virus and viral oncogenes expression was detected more rapidly using DisV-HPV16 compared to other software. DisV-HPV16 was proved highly convenient for detecting candidate virus after modification of the reference file. The accura

SUBMITTER: Yan B 

PROVIDER: S-EPMC6542142 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature