Association of the ACTN3 R577X (rs1815739) polymorphism with elite power sports: A meta-analysis.

ABSTRACT:

Objective

The special status accorded to elite athletes stems from their uncommon genetic potential to excel in world-class power sports (PS). Genetic polymorphisms have been reported to influence elite PS status. Reports of associations between the α-actinin-3 gene (ACTN3) R577X polymorphism and PS have been inconsistent. In light of new published studies, we perform a meta-analysis to further explore the roles of this polymorphism in PS performance among elite athletes.

Methods

Multi-database literature search yielded 44 studies from 38 articles. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used in estimating associations (significance threshold was set at Pa ≤ 0.05) using the allele-genotype model (R and X alleles, RX genotype). Outlier analysis was us

SUBMITTER: Tharabenjasin P 

PROVIDER: S-EPMC6542526 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature