Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease.

ABSTRACT:

Introduction

Primary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer's disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects with PART and AD pathology.

Methods

Brain autopsies (n = 183) were conducted on participants 85 years and older from the Baltimore Longitudinal Study of Aging and Johns Hopkins Alzheimer's Disease Research Center. Participants, normal at enrollment, were followed with periodic cognitive evaluations until death.

Results

Compared with AD, PART subjects showed significantly slower rates of decline on measures of memory, language, and visuospatial performance. They also sh

SUBMITTER: Bell WR 

PROVIDER: S-EPMC6542566 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature