Single cell transcriptomics based-MacSpectrum reveals novel macrophage activation signatures in diseases.

ABSTRACT: Adipose tissue macrophages (ATM) are crucial for maintaining adipose tissue homeostasis and mediating obesity-induced metabolic abnormalities, including prediabetic conditions and type 2 diabetes mellitus. Despite their key functions in regulating adipose tissue metabolic and immunologic homeostasis under normal and obese conditions, a high-resolution transcriptome annotation system that can capture ATM multifaceted activation profiles has not yet been developed. This is primarily attributed to the complexity of their differentiation/activation process in adipose tissue and their diverse activation profiles in response to microenvironmental cues. Although the concept of multifaceted macrophage action is well-accepted, no current model precisely depicts their dynamically regulated in vivo f

SUBMITTER: Li C 

PROVIDER: S-EPMC6542613 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature