Disrupted core-periphery structure of multimodal brain networks in Alzheimer's disease.

ABSTRACT: In Alzheimer's disease (AD), the progressive atrophy leads to aberrant network reconfigurations both at structural and functional levels. In such network reorganization, the core and peripheral nodes appear to be crucial for the prediction of clinical outcome because of their ability to influence large-scale functional integration. However, the role of the different types of brain connectivity in such prediction still remains unclear. Using a multiplex network approach we integrated information from DWI, fMRI, and MEG brain connectivity to extract an enriched description of the core-periphery structure in a group of AD patients and age-matched controls. Globally, the regional coreness-that is, the probability of a region to be in the multiplex core-significantly decreased in AD patients as

SUBMITTER: Guillon J 

PROVIDER: S-EPMC6542619 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature