Localized rest and stress human cardiac creatine kinase reaction kinetics at 3 T.

ABSTRACT: Changes in the kinetics of the creatine kinase (CK) shuttle are sensitive markers of cardiac energetics but are typically measured at rest and in the prone position. This study aims to measure CK kinetics during pharmacological stress at 3 T, with measurement in the supine position. A shorter "stressed saturation transfer" (StreST) extension to the triple repetition time saturation transfer (TRiST) method is proposed. We assess scanning in a supine position and validate the MR measurement against biopsy assay of CK activity. We report normal ranges of stress CK forward rate (k_f^CK ) for healthy volunteers and obese patients. TRiST measures k_f^CK in 40 min at 3 T. StreST extends the previously developed TRiST to also make a further k_f

SUBMITTER: Clarke WT 

PROVIDER: S-EPMC6542687 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature