AbPredict 2: a server for accurate and unstrained structure prediction of antibody variable domains.

ABSTRACT:

Summary

Methods for antibody structure prediction rely on sequence homology to experimentally determined structures. Resulting models may be accurate but are often stereochemically strained, limiting their usefulness in modeling and design workflows. We present the AbPredict 2 web-server, which instead of using sequence homology, conducts a Monte Carlo-based search for low-energy combinations of backbone conformations to yield accurate and unstrained antibody structures.

Availability and implementation

We introduce several important improvements over the previous AbPredict implementation: (i) backbones and sidechains are now modeled using ideal bond lengths and angles, substantially reducing stereochemical strain, (ii) sampling of the rigid-body orientation at the light-heav

SUBMITTER: Lapidoth G 

PROVIDER: S-EPMC6542689 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature