Common variation within the SETBP1 gene is associated with reading-related skills and patterns of functional neural activation.

ABSTRACT: Epidemiological population studies highlight the presence of substantial individual variability in reading skill, with approximately 5-10% of individuals characterized as having specific reading disability (SRD). Despite reported substantial heritability, typical for a complex trait, the specifics of the connections between reading and the genome are not understood. Recently, the SETBP1 gene has been implicated in several complex neurodevelopmental syndromes and disorders that impact language. Here, we examined the relationship between common polymorphisms in this gene, reading, and reading associated behaviors using data from an ongoing project on the genetic basis of SRD (n = 135). In addition, an exploratory analysis was conducted to examine the relationship between SETBP1 and brain act

SUBMITTER: Perdue MV 

PROVIDER: S-EPMC6542718 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature