Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP.

ABSTRACT: GABAergic circuits are critical for the synchronization and higher order function of brain networks. Defects in this circuitry are linked to neuropsychiatric diseases, including bipolar disorder, schizophrenia, and autism. Work in cultured neurons has shown that ankyrin-G plays a key role in the regulation of GABAergic synapses on the axon initial segment and somatodendritic domain of pyramidal neurons, where it interacts directly with the GABA_A receptor-associated protein (GABARAP) to stabilize cell surface GABA_A receptors. Here, we generated a knock-in mouse model expressing a mutation that abolishes the ankyrin-G/GABARAP interaction (Ank3 W1989R) to understand how ankyrin-G and GABARAP regulate GABAergic circuitry in vivo. We found that Ank3 W1989R mice exhibit a s

SUBMITTER: Nelson AD 

PROVIDER: S-EPMC6542726 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature