Concussion Pathophysiology and Injury Biomechanics.

ABSTRACT:

Purpose of review

The concussion public health burden has increased alongside our knowledge of the pathophysiology of mild traumatic brain injury (mTBI). The purpose of this review is to summarize our current understanding of mTBI pathophysiology and biomechanics and how these underlying principles correlate with clinical manifestations of mTBI.

Recent findings

Changes in post-mTBI glutamate and GABA concentrations seem to be region-specific and time-dependent. Genetic variability may predict recovery and symptom severity while gender differences appear to be associated with the neuroinflammatory response and neuroplasticity. Ongoing biomechanical research has shown a growing body of evidence in support of an "individual-specific threshold" for mTBI that varies based on indi

SUBMITTER: Romeu-Mejia R 

PROVIDER: S-EPMC6542913 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature