Disordered gut microbiota and alterations in metabolic patterns are associated with atrial fibrillation.

ABSTRACT:

Background

With the establishment of the heart-gut axis concept, accumulating studies suggest that the gut microbiome plays an important role in the pathogenesis of cardiovascular diseases. Yet, little evidence has been reported in characterizing the gut microbiota shift in atrial fibrillation.

Methods

We include the result of the global alterations that occur in the intestinal microbiota in a cohort of 50 patients with atrial fibrillation and 50 matched controls based on a strategy of metagenomic and metabolomic analyses.

Results

The alterations include a dramatic elevation in microbial diversity and a specific perturbation of gut microbiota composition. Overgrowth of Ruminococcus, Streptococcus, and Enterococcus, as well as reduction of Faecalibacterium, Alistipes,

SUBMITTER: Zuo K 

PROVIDER: S-EPMC6543127 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature