Evaluating the evidence for biotypes of depression: Methodological replication and extension of.

ABSTRACT: BACKGROUND:Psychiatric disorders are highly heterogeneous, defined based on symptoms with little connection to potential underlying biological mechanisms. A possible approach to dissect biological heterogeneity is to look for biologically meaningful subtypes. A recent study Drysdale et al. (2017) showed promising results along this line by simultaneously using resting state fMRI and clinical data and identified four distinct subtypes of depression with different clinical profiles and abnormal resting state fMRI connectivity. These subtypes were predictive of treatment response to transcranial magnetic stimulation therapy. OBJECTIVE:Here, we attempted to replicate the procedure followed in the Drysdale et al. study and their findings in a different clinical population and a more heterogeneo

SUBMITTER: Dinga R 

PROVIDER: S-EPMC6543446 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature