Technical feasibility of [¹⁸F]FET and [¹⁸F]FAZA PET guided radiotherapy in a F98 glioblastoma rat model.

ABSTRACT:

Background

Glioblastoma (GB) is the most common primary malignant brain tumor. Standard medical treatment consists of a maximal safe surgical resection, subsequently radiation therapy (RT) and chemotherapy with temozolomide (TMZ). An accurate definition of the tumor volume is of utmost importance for guiding RT. In this project we investigated the feasibility and treatment response of subvolume boosting to a PET-defined tumor part.

Method

F98 GB cells inoculated in the rat brain were imaged using T2- and contrast-enhanced T1-weighted (T1w) MRI. A dose of 20 Gy (5 × 5 mm²) was delivered to the target volume delineated based on T1w MRI for three treatment groups. Two of those treatment groups received an additional radiation boost of 5 Gy (1 × 1 mm²) deli

SUBMITTER: Verhoeven J 

PROVIDER: S-EPMC6543630 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature