The XN-30 hematology analyzer for rapid sensitive detection of malaria: a diagnostic accuracy study.

ABSTRACT:

Background

Accurate and timely diagnosis of malaria is essential for disease management and surveillance. Thin and thick blood smear microscopy and malaria rapid diagnostic tests (RDTs) are standard malaria diagnostics, but both methods have limitations. The novel automated hematology analyzer XN-30 provides standard complete blood counts (CBC) as well as quantification of malaria parasitemia at the price of a CBC. This study assessed the accuracy of XN-30 for malaria detection in a controlled human malaria infection (CHMI) study and a phase 3 diagnostic accuracy study in Burkina Faso.

Methods

Sixteen healthy, malaria-naive CHMI participants were challenged with five Plasmodium falciparum-infected mosquitoes. Blood was sampled daily for XN-30, blood smear microscopy, and mal

SUBMITTER: Post A 

PROVIDER: S-EPMC6543632 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature