Suppression of NLRP3 inflammasome improves alveolar bone defect healing in diabetic rats.

ABSTRACT:

Background

Excessive inflammatory response under hyperglycemia can impair alveolar bone defect healing under diabetic conditions. NLRP3 (NACHT [nucleotide-binding oligomerization], LRR [leucine-rich repeat], and PYD [pyrin domain] domains-containing protein 3) inflammasome has been considered to play a crucial role in the inflammatory response, but its correlation with the impaired alveolar bone repair in diabetes still remains unclarified. The objective of the current study is to investigate the effect of NLRP3 inflammasome inhibition by a lentiviral short hairpin RNA (shRNA) targeting NLRP3 on alveolar bone defect healing in diabetic rats.

Methods

Diabetes was induced in rats by high-fat diet and streptozotocin injection, and alveolar bone defects in both maxillae were cre

SUBMITTER: Li H 

PROVIDER: S-EPMC6543640 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature