Systems Analysis of the Human Pulmonary Arterial Hypertension Lung Transcriptome.

ABSTRACT: Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary artery pressure and vascular resistance, typically leading to right heart failure and death. Current therapies improve quality of life of the patients but have a modest effect on long-term survival. A detailed transcriptomics and systems biology view of the PAH lung is expected to provide new testable hypotheses for exploring novel treatments. We completed transcriptomics analysis of PAH and control lung tissue to develop disease-specific and clinical data/tissue pathology gene expression classifiers from expression datasets. Gene expression data were integrated into pathway analyses. Gene expression microarray data were collected from 58 PAH and 25 control lung tissues. The strength of the dataset and its derive

SUBMITTER: Stearman RS 

PROVIDER: S-EPMC6543748 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature