The Impact of Natural Selection on Short Insertion and Deletion Variation in the Great Tit Genome.

ABSTRACT: Insertions and deletions (INDELs) remain understudied, despite being the most common form of genetic variation after single nucleotide polymorphisms. This stems partly from the challenge of correctly identifying the ancestral state of an INDEL and thus identifying it as an insertion or a deletion. Erroneously assigned ancestral states can skew the site frequency spectrum, leading to artificial signals of selection. Consequently, the selective pressures acting on INDELs are, at present, poorly resolved. To tackle this issue, we have recently published a maximum likelihood approach to estimate the mutation rate and the distribution of fitness effects for INDELs. Our approach estimates and controls for the rate of ancestral state misidentification, overcoming issues plaguing previous INDEL st

SUBMITTER: Barton HJ 

PROVIDER: S-EPMC6543879 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature