Longitudinal trends in serum ferritin levels and associated factors in a national incident hemodialysis cohort.

ABSTRACT:

Background

The rise in serum ferritin levels among US maintenance hemodialysis patients has been attributed to higher intravenous iron administration and other changes in practice. We examined ferritin trends over time in hemodialysis patients and whether iron utilization patterns and other factors [erythropoietin-stimulating agent (ESA) prescribing patterns, inflammatory markers] were associated with ferritin trajectory.

Methods

In a 5-year (January 2007–December 2011) cohort of 81 864 incident US hemodialysis patients, we examined changes in ferritin averaged over 3-month intervals using linear mixed effects models adjusted for intravenous iron dose, malnutrition and inflammatory markers. We then examined ferritin trends across strata of baseline ferritin level, dialysis i

SUBMITTER: Kim T 

PROVIDER: S-EPMC6543884 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature