Implication of Melanopsin and Trigeminal Neural Pathways in Blue Light Photosensitivity in vivo.

ABSTRACT: Photophobia may arise from various causes and frequently accompanies numerous ocular diseases. In modern highly illuminated world, complaints about greater photosensitivity to blue light increasingly appear. However, the pathophysiology of photophobia is still debated. In the present work, we investigated in vivo the role of various neural pathways potentially implicated in blue-light aversion. Moreover, we studied the light-induced neuroinflammatory processes on the ocular surface and in the trigeminal pathways. Adult male C57BL/6J mice were exposed either to blue (400-500 nm) or to yellow (530-710 nm) LED light (3 h, 6 mW/cm²). Photosensitivity was measured as the time spent in dark or illuminated parts of the cage. Pharmacological treatments were applied: topical insti

SUBMITTER: Marek V 

PROVIDER: S-EPMC6543920 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature