The Design of FluxML: A Universal Modeling Language for ¹³C Metabolic Flux Analysis.

ABSTRACT: ¹³C metabolic flux analysis (MFA) is the method of choice when a detailed inference of intracellular metabolic fluxes in living organisms under metabolic quasi-steady state conditions is desired. Being continuously developed since two decades, the technology made major contributions to the quantitative characterization of organisms in all fields of biotechnology and health-related research. ¹³C MFA, however, stands out from other "-omics sciences," in that it requires not only experimental-analytical data, but also mathematical models and a computational toolset to infer the quantities of interest, i.e., the metabolic fluxes. At present, these models cannot be conveniently exchanged between different labs. Here, we present the implementation-independent model descript

SUBMITTER: Beyß M 

PROVIDER: S-EPMC6543931 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature