Pregnancy in human IAPP transgenic mice recapitulates beta cell stress in type 2 diabetes.

ABSTRACT:

Aims/hypothesis

Islet amyloid polypeptide (IAPP) misfolding and toxic oligomers contribute to beta cell loss and stress in type 2 diabetes. Pregnancy-related diabetes predicts subsequent risk for type 2 diabetes but little is known about the impact of pregnancy on beta cell mass, turnover and stress. Availability of human pancreas tissue in pregnancy is limited and most widely used mouse models of type 2 diabetes do not develop pregnancy-related diabetes, possibly because rodent IAPP is not prone to form toxic oligomers. We hypothesised that mice transgenic for human IAPP (hIAPP) are prone to pregnancy-related diabetes with beta cell responses reflective of those in type 2 diabetes.

Methods

We evaluated the impact of a first and second pregnancy on glucose homeostasis, beta

SUBMITTER: Gurlo T 

PROVIDER: S-EPMC6544020 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature