PEGylated rhenium nanoclusters: a degradable metal photothermal nanoagent for cancer therapy.

ABSTRACT: A common issue of functional nanoagents for potential clinical translation is whether they are biodegradable or renal clearable. Previous studies have widely explored noble metal nanoparticles (Au and Pd) as the first generation of photothermal nanoagents for cancer therapy, but all of the reported noble metal nanoparticles are non-degradable. On the other hand, rhenium (Re), one of the noble and precious metals with a high atomic number (Z = 75), has been mainly utilized as a jet superalloy or chemical catalyst, but the biological characteristics and activity of Re nanoparticles have never been evaluated until now. To address these issues, here we report a simple and scalable liquid-reduction strategy to synthesize PEGylated Re nanoclusters, which exhibit intrinsically high phototh

SUBMITTER: Miao Z 

PROVIDER: S-EPMC6544121 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature