Protein Folding Modulation in Cells Subject to Differentiation and Stress.

ABSTRACT: Cytomimetic media are used to mimic the physicochemical properties of the cellular milieu in an in vitro experiment. The motivation is that compared to entire cells, they can be used efficiently in combination with a broad range of experimental techniques. However, the development and use of cytomimetic media is hampered by the lack of in-cell data that could be used as a hallmark to directly evaluate and improve the performance of cytomimetic media in different applications. Such data must include the study of specific biomolecular reactions in different cell types, different compartments of a single cells and different cellular conditions. In previous studies, model systems such as cancer cell lines, bacteria or oocytes were used. Here we studied how the environment of cells that

SUBMITTER: Gnutt D 

PROVIDER: S-EPMC6544126 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature