World Workshop of Oral Medicine VII: A systematic review of immunobiologic therapy for oral manifestations of pemphigoid and pemphigus.

ABSTRACT:

Objective

To assess the evidence for treatment of oral involvement of pemphigus and pemphigoid with biologics.

Study design

This systematic review used a comprehensive search strategy to identify literature describing oral involvement of pemphigus or pemphigoid treated with a biologic agent. The primary outcome measures were efficacy and safety of biologic therapy.

Results

Inclusion criteria were met by 154 studies including over 1200 patients. Treatment of pemphigus with a total of 11 unique biologic agents and 3 unique combinations of agents is reported. Five randomized controlled trials (RCT) were included in the final analysis that investigated infliximab, IVIg, rituximab, and autologous platelet-rich plasma therapy for pemphigus vulgaris. Three non-RCT studies re

SUBMITTER: Mays JW 

PROVIDER: S-EPMC6544168 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature