World Workshop on Oral Medicine VII: Immunobiologics for salivary gland disease in Sjogren's syndrome: A systematic review.

ABSTRACT:

Objective

This systematic review evaluated the efficacy of immunobiologics for the management of oral disease in Sjögren's syndrome (SS).

Materials and methods

MEDLINE^® , Embase, Scopus, and the Cochrane Library were searched for evidence on the use of immunobiologics for management of glandular disease in SS. Primary outcomes were xerostomia and salivary gland dysfunction, assessed via visual analogue scales, disease-specific scales for SS, measurement of salivary flow, ultrasound data, and quality of life measures.

Results

Seventeen studies (11 randomized controlled trials and 6 observational studies) met inclusion criteria. Rituximab showed efficacy in improving salivary gland function but not xerostomia. Abatacept showed promise in improving both xerost

SUBMITTER: Gueiros LA 

PROVIDER: S-EPMC6544171 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature