Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection.

ABSTRACT: Leptospira interrogans are pathogenic spirochetes responsible for leptospirosis, a worldwide reemerging zoonosis. Many Leptospira serovars have been described, and prophylaxis using inactivated bacteria provides only short-term serovar-specific protection. Therefore, alternative approaches to limit severe leptospirosis in humans and morbidity in cattle would be welcome. Innate immune cells, including macrophages, play a key role in fighting infection and pathogen clearance. Recently, it has been shown that functional reprograming of innate immune cells through the activation of pattern recognition receptors leads to enhanced nonspecific antimicrobial responses upon a subsequent microbial encounter. This mechanism is known as trained immunity or innate immune memory. We have previously show

SUBMITTER: Santecchia I 

PROVIDER: S-EPMC6544334 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature