IgG based immunome analyses of breast cancer patients reveal underlying signaling pathways.

ABSTRACT: Background: Breast cancer is the most frequent and one of the most fatal malignancies among women. Within the concept of personalized medicine, molecular characterization of tumors is usually performed by analyzing somatic mutations, RNA gene expression signatures or the proteome by mass-spectrometry. Alternatively, the immunological fingerprint of the patients can be analyzed by protein microarrays, which is able to provide another layer of molecular pathological information without invasive intervention. Results: We have investigated the immune signature of breast cancer patients and compared them with healthy controls, using protein microarray-based IgG profiling. The identified differentially reactive antigens (n=517) were further evaluated by means of various pathway ana

SUBMITTER: Gyurjan I 

PROVIDER: S-EPMC6544406 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature