Positive and general psychopathology associated with specific gray matter reductions in inferior temporal regions in patients with schizophrenia.

ABSTRACT: Schizophrenia is a complex disorder that affects perception, cognition, and emotion causing symptoms such as delusions, hallucinations, and suspiciousness. Schizophrenia is also associated with structural cortical abnormalities including lower gray matter (GM) concentration, GM volume, and cortical thickness relative to healthy control individuals. However, the association between GM measures and symptom dimensions in schizophrenia is still not well understood. Here, we applied parallel independent component analysis (pICA), a higher-order statistical approach that identifies covarying patterns within two (or more) data modalities simultaneously, to link covarying brain networks of GM concentration with covarying linear combinations of the positive and negative syndrome scale (PANSS). In a

SUBMITTER: Mennigen E 

PROVIDER: S-EPMC6544466 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature