Membrane transporters in traumatic brain injury: Pathological, pharmacotherapeutic, and developmental implications.

ABSTRACT: Membrane transporters regulate the trafficking of endogenous and exogenous molecules across biological barriers and within the neurovascular unit. In traumatic brain injury (TBI), they moderate the dynamic movement of therapeutic drugs and injury mediators among neurons, endothelial cells and glial cells, thereby becoming important determinants of pathogenesis and effective pharmacotherapy after TBI. There are three ways transporters may impact outcomes in TBI. First, transporters likely play a key role in the clearance of injury mediators. Second, genetic association studies suggest transporters may be important in the transition of TBI from acute brain injury to a chronic neurological disease. Third, transporters dynamically control the brain penetration and efflux of many drugs and thei

SUBMITTER: Hagos FT 

PROVIDER: S-EPMC6544476 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature