Ontology highlight
ABSTRACT:
SUBMITTER: Domingo-Calap P
PROVIDER: S-EPMC6544518 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Domingo-Calap Pilar P Segredo-Otero Ernesto E Durán-Moreno María M Sanjuán Rafael R
Nature microbiology 20190304 6
Antiviral immunity has been studied extensively from the perspective of virus-cell interactions, yet the role of virus-virus interactions remains poorly addressed. Here, we demonstrate that viral escape from interferon (IFN)-based innate immunity is a social process in which IFN-stimulating viruses determine the fitness of neighbouring viruses. We propose a general and simple social evolution framework to analyse how natural selection acts on IFN shutdown and validate it in cell cultures and mic ...[more]