Immunoproteasome activation enables human TRIM5α restriction of HIV-1.

ABSTRACT: Type 1 interferon suppresses viral replication by upregulating the expression of interferon-stimulated genes with diverse antiviral properties¹. The replication of human immunodeficiency virus type 1 (HIV-1) is naturally inhibited by interferon, with the steps between viral entry and chromosomal integration of viral DNA being notably susceptible^2-5. The interferon-stimulated gene myxovirus resistance 2 has been defined as an effective postentry inhibitor of HIV-1, but is only partially responsible for interferon's suppressive effect^6-8. Using small interfering RNA-based library screening in interferon-α-treated cells, we sought to characterize further interferon-stimulated genes that target the pre-integration phases of HIV-1 infection, and identified human

SUBMITTER: Jimenez-Guardeno JM 

PROVIDER: S-EPMC6544544 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature