Altered human oligodendrocyte heterogeneity in multiple sclerosis.

ABSTRACT: Oligodendrocyte pathology is increasingly implicated in neurodegenerative diseases as oligodendrocytes both myelinate and provide metabolic support to axons. In multiple sclerosis (MS), demyelination in the central nervous system thus leads to neurodegeneration, but the severity of MS between patients is very variable. Disability does not correlate well with the extent of demyelination¹, which suggests that other factors contribute to this variability. One such factor may be oligodendrocyte heterogeneity. Not all oligodendrocytes are the same-those from the mouse spinal cord inherently produce longer myelin sheaths than those from the cortex², and single-cell analysis of the mouse central nervous system identified further differences^3,4. However, the extent

SUBMITTER: Jakel S 

PROVIDER: S-EPMC6544546 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature