Correlation between ¹⁸F-1-amino-3-fluorocyclobutane-1-carboxylic acid (¹⁸F-fluciclovine) uptake and expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter 1 (LAT1) in primary prostate cancer.

ABSTRACT:

Purpose

To evaluate the expression of alanine-serine-cysteine-transporter 2 (ASCT2) and L-type amino acid transporter1 (LAT1) in prostate cancer (PCa) and their impact on uptake of ¹⁸F-1-amino-3-fluorocyclobutane-1-carboxylic acid (¹⁸F-fluciclovine) which is approved for the detection of recurrent PCa.

Methods

Twenty-five hormone-naïve patients with histologically confirmed PCa underwent PET/CT before prostatectomy. Dynamic imaging was performed immediately after injection of 368 ± 10 MBq of ¹⁸F-fluciclovine and the uptake in PCa was expressed as SUV_max at six sequential 4-min time frames and as tracer distribution volume (V_T) using Logan plots over 0-24 min. The expression of ASCT2 and LAT1 was studied with immunohistoc

SUBMITTER: Saarinen I 

PROVIDER: S-EPMC6544711 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature