Novel individualized power training protocol preserves physical function in adult and older mice.

ABSTRACT: Sarcopenia, the age-related loss of muscle mass and strength, contributes to frailty, functional decline, and reduced quality of life in older adults. Exercise is a recognized therapy for sarcopenia and muscle dysfunction, though not a cure. Muscle power declines at an increased rate compared to force, and force output declines earlier than mass. Thus, there is a need for research of exercise focusing on improving power output and functionality in older adults. Our primary purpose was proof-of-concept that a novel individualized power exercise modality would induce positive adaptations in adult mice, before the exercise program was applied to an aged cohort. We hypothesized that after following our protocol, both adult and older mice would show improved function, though there would be evid

SUBMITTER: Graber TG 

PROVIDER: S-EPMC6544743 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature