Sodium channel blockers for cystic fibrosis.

ABSTRACT:

Background

People with cystic fibrosis (CF) have increased transport of the salt, sodium across their airway lining. Over-absorption of sodium results in the dehydration of the liquid that lines the airway surface and (along with defective chloride secretion) is a primary defect in people with CF.

Objectives

To determine whether the topical administration of drugs that block sodium transport improves the respiratory condition of people with CF.

Search methods

We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register comprising references identified from comprehensive electronic database searches, handsearching relevant journals and abstract books of conference proceedings. We contacted principal investigators known to work in the field, prev

SUBMITTER: Burrows EF 

PROVIDER: S-EPMC6544779 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature