CCL20-CCR6 axis modulated traumatic brain injury-induced visual pathologies.

ABSTRACT:

Background

Traumatic brain injury (TBI) is a major cause of death and disability in the USA and the world; it constitutes 30% of injury-related deaths (Taylor et al., MMWR Surveill Summ 66:1-16, 2017). Contact sports athletes often experience repetitive TBI (rTBI), which exerts a cumulative effect later in life. Visual impairment is a common after-effect of TBI. Previously, we have shown that C-C chemokine 20 (CCL20) plays a critical role in neurodegeneration and inflammation following TBI (Das et al., J Neuroinflammation 8:148, 2011). C-C chemokine receptor 6 (CCR6) is the only receptor that CCL20 interacts with. The objective of the present study was to investigate the role of CCL20-CCR6 axis in mediating rTBI-induced visual dysfunction (TVD).

Methods

Wild type (WT) or CCR

SUBMITTER: Das M 

PROVIDER: S-EPMC6544928 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature