Dysbiosis of the intestinal microbiota in neurocritically ill patients and the risk for death.

ABSTRACT:

Background

Despite the essential functions of the intestinal microbiota in human physiology, little has been reported about the microbiome in neurocritically ill patients. This investigation aimed to evaluate the characteristics of the gut microbiome in neurocritically ill patients and its changes after admission. Furthermore, we investigated whether the characteristics of the gut microbiome at admission were a risk factor for death within 180 days.

Methods

This prospective observational cohort study included neurocritically ill patients admitted to the neurological intensive care unit of a large university-affiliated academic hospital in Guangzhou. Faecal samples were collected within 72 h after admission (before antibiotic treatment) and serially each week. Healthy volunte

SUBMITTER: Xu R 

PROVIDER: S-EPMC6544929 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature