Interpreting the MicroRNA-15/107 family: interaction identification by combining network based and experiment supported approach.

ABSTRACT:

Background

The highly conservative miR-15/107 family (also named as miR-15/107 gene group) including ten miRNA members is currently recognized strongly implicated in multiple human disorders. Some studies focus on the entire family rather than individual miRNA for a bigger picture, while there is also certain signature dysregulation for some of the individual miRNA implicated even in the same disorder.

Methods

Faced with the exponential growth of experimental evidence, our study tries to analyze their function and target interactions using various bioinformatics tools.

Results

Firstly, the evolutionary conservative "AGCAGC" sequence and possible clustered transcriptional pattern were described. Secondly, both the experimentally validated and bioinformatically predicte

SUBMITTER: Wang S 

PROVIDER: S-EPMC6544937 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature