Dynamics of gene regulatory networks and their dependence on network topology and quantitative parameters - the case of phage λ.

ABSTRACT:

Background

Gene regulatory networks can be modelled in various ways depending on the level of detail required and biological questions addressed. One of the earliest formalisms used for modeling is a Boolean network, although these models cannot describe most temporal aspects of a biological system. Differential equation models have also been used to model gene regulatory networks, but these frameworks tend to be too detailed for large models and many quantitative parameters might not be deducible in practice. Hybrid models bridge the gap between these two model classes - these are useful when concentration changes are important while the information about precise concentrations and binding site affinities is partial.

Results

In this paper we study the stable behaviours of p

SUBMITTER: Ruklisa D 

PROVIDER: S-EPMC6544977 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature