Production and characterization of two medium-chain-length polydroxyalkanoates by engineered strains of Yarrowia lipolytica.

ABSTRACT:

Background

The oleaginous yeast Yarrowia lipolytica is an organism of choice for the tailored production of various compounds such as biofuels or biopolymers. When properly engineered, it is capable of producing medium-chain-length polyhydroxyalkanoate (mcl-PHA), a biobased and biodegradable polymer that can be used as bioplastics or biopolymers for environmental and biomedical applications.

Results

This study describes the bioproduction and the main properties of two different mcl-PHA polymers. We generated by metabolic engineering, strains of Y. lipolytica capable of accumulating more than 25% (g/g) of mcl-PHA polymers. Depending of the strain genetic background and the culture conditions, we produced (i) a mcl-PHA homopolymer of 3-hydroxydodecanoic acids, with a mass-aver

SUBMITTER: Rigouin C 

PROVIDER: S-EPMC6545009 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature