Expression dynamics of repetitive DNA in early human embryonic development.

ABSTRACT:

Background

The last decade witnessed a number of genome-wide studies on human pre-implantation, which mostly focused on genes and provided only limited information on repeats, excluding the satellites. Considering the fact that repeats constitute a large portion of our genome with reported links to human physiology and disease, a thorough understanding of their spatiotemporal regulation during human embryogenesis will give invaluable clues on chromatin dynamics across time and space. Therefore, we performed a detailed expression analysis of all repetitive DNA elements including the satellites across stages of human pre-implantation and embryonic stem cells.

Results

We uncovered stage-specific expressions of more than a thousand repeat elements whose expressions fluctuated wi

SUBMITTER: Yandım C 

PROVIDER: S-EPMC6545021 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature