Who says "no" to participating in stroke clinical trials and why: an observational study from the Vancouver Stroke Program.

ABSTRACT:

Background

Successful stroke trials require adequate recruitment. In this observational study, we assessed reasons for refusal to provide informed consent in eligible patients approached for clinical trial participation at the Vancouver Stroke Program.

Methods

We assessed screening logs from four trials that were actively recruiting at our center: three randomized trials, two of which investigated different antithrombotic strategies for secondary prevention (NAVIGATE-ESUS, NCT02313909 12/2014; DATAS-II, NCT02295826 11/2014) and one that investigated surgery plus medical management versus medical management alone for primary prevention (CREST-2, NCT02089217 03/2014). The fourth study was observational and non-randomized; all participants received an external monitoring device

SUBMITTER: O'Neill ZR 

PROVIDER: S-EPMC6545028 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature