Rutin ameliorates carbon tetrachloride (CCl₄)-induced hepatorenal toxicity and hypogonadism in male rats.

ABSTRACT: Rutin, a food derived-polyphenolic bioflavonoid, has been acknowledged for several health benefits. This study aims to explore the ameliorative effects of rutin against carbon tetrachloride (CCl₄) toxicity in male rats. Adult male rats were given either CCl₄ (30% in olive oil, 3 ml/kg b.w. intraperitoneally) alone or in combination with rutin (70 mg/kg intragastrically) twice a week for 4 weeks. Our data showed that rutin mitigated CCl₄ hepatorenal damage, as indicated by diagnostic markers (i.e., transaminases, alkaline phosphatase, total bilirubin, total protein, albumin, urea, uric acid and creatinine), and histopathological findings. In addition, CCl₄ induced profound elevation of free radical generation and oxidative stress, as evidenced by

SUBMITTER: Elsawy H 

PROVIDER: S-EPMC6545103 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature