Distributed Plasticity Drives Visual Habituation Learning in Larval Zebrafish.

ABSTRACT: Habituation is a simple form of learning where animals learn to reduce their responses to repeated innocuous stimuli [1]. Habituation is thought to occur via at least two temporally and molecularly distinct mechanisms, which lead to short-term memories that last for seconds to minutes and long-term memories that last for hours or longer [1, 2]. Here, we focus on long-term habituation, which, due to the extended time course, necessitates stable alterations to circuit properties [2-4]. In its simplest form, long-term habituation could result from a plasticity event at a single point in a circuit, and many studies have focused on identifying the site and underlying mechanism of plasticity [5-10]. However, it is possible that these individual sites are only one of many points in the circuit wh

SUBMITTER: Randlett O 

PROVIDER: S-EPMC6545104 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature