Associations of transcranial doppler velocity, age, and gender with cognitive function in children with sickle cell anemia in Nigeria.

ABSTRACT: Children with sickle cell anemia (SCA) have elevated cerebral blood velocity relative to healthy peers. The primary aim of this study was to evaluate the association between cerebral blood velocity, measured by transcranial Doppler (TCD) ultrasound, age, and gender with cognitive function in children with SCA in Nigeria. Eighty-three children (M_age = 9.10, SD = 1.90 years; 55% female) with SCA in Nigeria completed cognitive assessments and a TCD ultrasound. The association between TCD velocity and measures of perceptual reasoning (Raven's Progressive Matrices), working memory (WISC-IV Digit Span), and executive planning (Tower of London, TOL) were assessed. Results showed that elevated TCD velocity significantly predicted lower scores on TOL Time Violations and Total Problem-Sol

SUBMITTER: Prussien KV 

PROVIDER: S-EPMC6545195 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature