Comparison of long-term outcomes of young patients after a coronary event associated with familial hypercholesterolemia.

ABSTRACT:

Objective

Familial hypercholesterolemia (FH) is an important cause of premature coronary artery disease (CAD). Prognosis data are lacking in patients with FH and coronary artery disease particularly in the era of widespread statin use. We compared long-term prognosis between patients with and without FH after a coronary event.

Methods

In this retrospective study, 865 patients younger than 40 years of age with CAD were enrolled. FH was diagnosed based on the Dutch Lipid Clinic Network algorithm. Baseline characteristics, coronary angiographic findings and prognosis during median follow-up of 5 (3-8) years were compared between patients with or without FH.

Results

Definite or probable FH was detected in 37 patients (4.3%) and possible FH in 259 patients (29.9%). FH was

SUBMITTER: Wang X 

PROVIDER: S-EPMC6545205 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature