Differential medial temporal lobe and default-mode network functional connectivity and morphometric changes in Alzheimer's disease.

ABSTRACT: We report group level differential detection of medial temporal lobe resting-state functional connectivity disruption and morphometric changes in the transition from cognitively normal to early mild cognitive impairment in an age-, education- and gender-matched 105 subjects Alzheimer's Disease Neuroimaging Initiative dataset. In mild Alzheimer's Disease, but not early mild cognitive impairment, characteristic brain atrophy was detected in FreeSurfer estimates of subcortical and hippocampal subfield volumes and cortical thinning. By contrast, functional connectivity analysis detected earlier significant changes. In early mild cognitive impairment these changes involved medial temporal lobe regions of transentorhinal, perirhinal and entorhinal cortices (associated with the earliest stages of

SUBMITTER: Grajski KA 

PROVIDER: S-EPMC6545401 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature