Raw genome sequence data for 13 isogenic <i>Aspergillus fumigatus</i> strains isolated over a 2 year period from a patient with chronic granulomatous disease.

ABSTRACT: Azole-resistance in Aspergillus fumigatus is an emerging worldwide threat as it precludes the use of one of the 3 major classes of antifungal drugs to treat chronic and invasive aspergillosis [1]. In addition to the well-known environmental emergence of azole-resistant A. fumigatus strains, associated with the use of fungicides in agriculture [2], [3], the development of in-host resistance, facilitated by medical antifungal use, has been described [4]. Investigations involving linked sets of (isogenic) clinical isolates of A. fumigatus sequentially recovered from individual patients, are extremely important in order to improve our understanding of how azole resistance develops in-host. Here we present the whole genome sequences of 13 clinical isogenic A. fumigatus</

SUBMITTER: Ballard E 

PROVIDER: S-EPMC6545414 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature