Mechanistic insights from targeted molecular profiling of repolarization alternans in the intact human heart.

ABSTRACT:

Aims

Action potential duration (APD) alternans is an established precursor or arrhythmia and sudden cardiac death. Important differences in fundamental electrophysiological properties relevant to arrhythmia exist between experimental models and the diseased in vivo human heart. To investigate mechanisms of APD alternans using a novel approach combining intact heart and cellular cardiac electrophysiology in human in vivo.

Methods and results

We developed a novel approach combining intact heart electrophysiological mapping during cardiac surgery with rapid on-site data analysis to guide myocardial biopsies for laboratory analysis, thereby linking repolarization dynamics observed at the organ level with underlying ion channel expression. Alternans-susceptible and alternans-resi

SUBMITTER: Orini M 

PROVIDER: S-EPMC6545501 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature