Local actin nucleation tunes centrosomal microtubule nucleation during passage through mitosis.

ABSTRACT: Cells going through mitosis undergo precisely timed changes in cell shape and organisation, which serve to ensure the fair partitioning of cellular components into the two daughter cells. These structural changes are driven by changes in actin filament and microtubule dynamics and organisation. While most evidence suggests that the two cytoskeletal systems are remodelled in parallel during mitosis, recent work in interphase cells has implicated the centrosome in both microtubule and actin nucleation, suggesting the potential for regulatory crosstalk between the two systems. Here, by using both in vitro and in vivo assays to study centrosomal actin nucleation as cells pass through mitosis, we show that mitotic exit is accompanied by a burst in cytoplasmic actin filament format

SUBMITTER: Farina F 

PROVIDER: S-EPMC6545563 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature